International Health Regulations 2005 3rd edition

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World Health Organization 978 92 4 158049 6 World Health Organization 2016

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A central and historic responsibility for the World Health Organization (WHO) has been the 
management of the global regime for the control of the international spread of disease. Under Articles 
21(a) and 22, the Constitution of WHO confers upon the World Health Assembly the authority to 
adopt regulations “designed to prevent the international spread of disease” which, after adoption by 
the Health Assembly, enter into force for all WHO Member States that do not affirmatively opt out of 
them within a specified time period.

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